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David R. Mootoo, Ph.D.

Professor - Organic Chemistry

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Contact Information:

office 1305aN (tel 212-772-4356), lab 1306N (tel 212-650-3718), fax (dept) 212-772-5332, email dmootoo@hunter.cuny.edu

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Education:

B.S. & M.S.: University of the West Indies, Ph.D.: University of Maryland, Post-Doctoral Research: Duke University

Research Summary:

Our research centers on the design, synthesis and application of biomechanistic probes, and the development of new synthetic methodologies, with a heavy focus on glycomimetic molecules.

Selected Research Projects 

Selected Publications

Glycomimetics

Garg, H.; Francella, N.; Tony, K.A.; Augustin, L.A.; Fantini, J.; Barchi Jr, J.J.; Puri, A.; Mootoo; Blumenthal, R. Glycoside analogues of -galactosylceramide, a novel class of small molecule inhibitors for HIV-1 entry. Antiviral Res. 2008 80, 54-61.

Bachan, S.; Tony, K. A.; Kawamura, A.; Montenegro, D.; Joshi, A.; Garg, H. Synthesis and anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins. Bioorg. Med. Chem. 2013, 21, 6554-6564..

Hans, S.; Altiti, A. Mootoo, D. R. Synthesis of the C-glycoside of alpha-D-mannose-(1, 6)-myo-inositol. Org. Biomol. Chem. 2013, 11, 6952-6953.

Altiti, A. S.; Mootoo, D. R. Intramolecular nitrogen delivery for the synthesis of C-glycosphingolipids. Application to the C-Glycoside of the immunostimulant KRN 7000. Org. Lett. 2014, 16, 1466-1469. 

Altiti, A. S.; Bachan, S.; Alrowhani, W.; Mootoo, D. R. An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon. Org. Biomol. Chem. 2015, 13, 10328-10335.

Altiti, A.; Bachan, S.; Mootoo, D. R. The crotylation way to glycosphingolipids: Synthesis of analogues of KRN 7000. Org. Lett. 2016, 18, 4654-4657.

  

Natural Products

Li, X.; Li, J.; Mootoo, D. R. Synthesis of the ABCD trioxadispiroketal subunit of azaspiracid-1: An iodoetherification-dehydroiodination strategy for complex spiroketals. Org. Lett. 2007, 9, 4303-4306.

Li, J.; Todaro, L.J.; Mootoo, D. R. Synthesis of the AB subunit of angelmicin B through a tandem alkoxy radical fragmentation-etherification sequence. Org. Lett. 2008,10, 1337-1340.

Wang, F.; Kawamura, A. Mootoo, D. R. Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin. Bioorg. Med. Chem. 2008,16, 8413-8418.

Synthesis of an AB precursor to angelmicin B: Product diversification in the Suárez lactol fragmentation. Li, J.; Todaro, L.; Mootoo, D. R. Eur. J. Org. Chem. 2011, 6281-6287.

Synthetic studies on the bis-anthraquinoid core of the angelimicins. Li, J.; Mootoo, D. R. Synthesis 2013, 45, 2287-2293.