Contact Information:

office 1305a HN (tel 212-396-6322), dept fax 212-772-5332, email szh0007@hunter.cuny.edu

Education:

Ph.D. Columbia University, Postdoc: Columbia University

Research Summary

Research in the Zheng group focuses on the design and development of new synthetic methodologies and their application to the total synthesis of structurally complex and biologically active natural products.

Targets are selected in terms of novel molecular architecture and intriguing biological activity. In addition to the chemical synthesis of biological relevant target molecules and analogs, additional explorations into their mechanism of action will be made through interdisciplinary collaborations.

Selected Publications

Levine, M; Kenesky, C. S.; Zheng, S.; Quinn, J.; Breslow, R. “Synthesis and Catalytic Properties of Diverse Chiral Polyamines” Tetrahedron Lett. 2008, 49, 5746-5750.

Zheng, S.; Chan, C.; Furuuchi, T.; Wright, B. J. D.; Zhou, B.; Guo, J.; Danishefsky, S. J. “Stereospecific Formal Total Synthesis of Ecteinascidin 743.” Angew. Chem. Int. Ed. 2006, 45, 1754-1759.

Chan, C.; Zheng, S.; Zhou, B.; Guo, J.; Heid, R. M.; Wright, B. J. D.; Danishefsky, S. J. “The Solution to a Deep Stereochemical Conundrum: Studies toward the Tetrahydroisoquinoline   Alkaloids.” Angew. Chem. Int. Ed. 2006, 45, 1749-1754.

Chan, C.; Heid, R.; Zheng, S.; Guo, J.; Zhou, B.; Furuuchi, T.; Danishefsky, S. J. “Total Synthesis of Cribrostatin IV: Fine-tuning the Character of an Amide Bond by Remote Control.” J. Am. Chem. Soc. 2005, 127, 4596-4598.