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Shengping Zheng, Ph.D.

Assistant Professor - Organic Chemistry


Contact Information:

office 1305a HN (tel 212-396-6322), dept fax 212-772-5332, email


B.S. Nankai University, M.S. Beijing University and the University of Chicago, Ph.D. Columbia University, Postdoc, Columbia University

Research Summary

Research in the Zheng group focuses on the design and development of new synthetic methodologies and their application to the total synthesis of structurally complex and biologically active natural products.

Targets are selected in terms of novel molecular architecture and intriguing biological activity. In addition to the chemical synthesis of biological relevant target molecules and analogs, additional explorations into their mechanism of action will be made through interdisciplinary collaborations.

Selected Publications

Yin, Z.; Zhang, J.; Wu, J.; Green, R.; Li, S.; Zheng, S. “Synthesis of o-Chlorophenols via an Unexpected Nucleophilic Chlorination of Quinone Monoketals Mediated by N, N’-Dimethylhydrazine Dihydrochloride” Org. Biomol. Chem. 2014, 12, 2854-2858. 

Zhang, J.; Yin, Z.; Leonard, P.; Wu, J.; Sioson, K.; Liu, C.; Lapo, R.; Zheng, S. “A Variation of Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines” Angew. Chem. Int. Ed., 2013, 52, 1753-1757.

Yin, Z.; Zhang, J.; Wu, J.; Liu, C.; Sioson, K.; Devany, M.; Hu, C.; Zheng, S. “Double Hetero-Michael Addition of N-Substituted Hydroxylamines to Quinone Monoketals: Synthesis of Bridged Isoxazolidines” Org. Lett. 2013, 15, 3534-3537.

Zhang, J.; Wu, J.; Yin, Z.; Zeng, H.; Khanna, K.; Hu, C.; Zheng, S. “An Expedient Stereoselective and Chemoselective Synthesis of Bicyclic Oxazolidinones from Quinols and Isocyanates” Org. Biomol. Chem. 2013, 11, 2939-2942.

Wu, S.; Wu, J.; Yin, Z.; Zhang, J.; Long, C.; Kennelly, E.; Zheng, S. “Bioactive and Marker Compounds from Two Edible Dark-colored Myrciaria Fruits and the Synthesis of Jaboticabin” J. Agric. Food Chem. 2013, 61, 4035-4043.

Levine, M; Kenesky, C. S.; Zheng, S.; Quinn, J.; Breslow, R. “Synthesis and Catalytic Properties of Diverse Chiral Polyamines” Tetrahedron Lett. 2008, 49, 5746-5750.

Zheng, S.; Chan, C.; Furuuchi, T.; Wright, B. J. D.; Zhou, B.; Guo, J.; Danishefsky, S. J. “Stereospecific Formal Total Synthesis of Ecteinascidin 743.” Angew. Chem. Int. Ed. 2006, 45, 1754-1759.

Chan, C.; Zheng, S.; Zhou, B.; Guo, J.; Heid, R. M.; Wright, B. J. D.; Danishefsky, S. J. “The Solution to a Deep Stereochemical Conundrum: Studies toward the Tetrahydroisoquinoline Alkaloids.” Angew. Chem. Int. Ed. 2006, 45, 1749-1754.

Chan, C.; Heid, R.; Zheng, S.; Guo, J.; Zhou, B.; Furuuchi, T.; Danishefsky, S. J. “Total Synthesis of Cribrostatin IV: Fine-tuning the Character of an Amide Bond by Remote Control.” J. Am. Chem. Soc. 2005, 127, 4596-4598.