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Contact Information:

Office Location: Belfer Research Building, Room 430

Office Telephone: 212-896-0443

E-mail: bz102@hunter.cuny.edu

Education:

B.S. Yale University
Ph.D. California Institute of Technology
Postdoc Memorial Sloan Kettering Cancer Center

Research Summary:

The research in the Zeglis Laboratory focuses on the design, synthesis, preclinical validation, and clinical translation of novel pharmaceuticals for the imaging and therapy of disease, particularly cancer. We are particularly interested in work at the intersection of molecular imaging and bioorthogonal chemistry.

Lab Website: zeglislab.com

Selected Publications:

Adumeau, P., Sharma, S. K., Brent, C., Zeglis, B. M. “Site-Specifically Labeled Immunoconjugates for Molecular Imaging — Part 2: Peptide Tags and Unnatural Amino Acids” Mol. Imag. Biol. Online Ahead of Print (2016).

Adumeau, P., Sharma, S. K., Brent, C., Zeglis, B. M. “Site-Specifically Labeled Immunoconjugates for Molecular Imaging — Part 1: Cysteine Residues and Glycans” Mol. Imag. Biol. 18, 1 (2016).

Houghton, J. L., Zeglis, B. M., Abdel-Atti, D., Sawada, R., Scholz, W. W., Lewis, J. S. “Pretargeted ImmunoPET of Pancreatic Cancer: Overcoming Circulating Antigen and Antibody Internalization to Reduce Radiation Doses” J. Nucl. Med. Online Ahead of Print. (2015).

Meyer, J. -P., Houghton, J. L., Koslowski, P., Abdel-Atti, D., Reiner, T., Pillarsetty, N. V. K., Scholz, W. W., Zeglis, B. M.*, and Lewis, J. S.* “18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry” Bioconjugate Chem. Online Ahead of Print (2015). *Co-corresponding author

Houghton, J. L., Zeglis, B. M., Abdel-Atti, D., Aggeler, A., Sawada, R., Agnew, B. J., Scholz, W. W., Lewis, J. S. “Site-Specifically Labeled CA19.9-Targeted Immunoconjugates for the PET, NIRF, and Multimodal PET/NIRF Imaging of Pancreatic Cancer” Proc. Nat. Acad. Sci. U.S.A. 112(52), 15850 (2015).

Zeglis, B. M.*, Brand, C. Abdel-Atti, D., Carnazza, K., Cook, B., Carlin, S., Reiner, T., Lewis, J. S.* “Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics” Mol. Pharm. 25, 3575 (2015). *Co-corresponding author