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Shengping Zheng, Ph.D.

Associate Professor - Organic Chemistry

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Contact Information:

office 1305a HN (tel 212-396-6322), dept fax 212-772-5332, email szh0007@hunter.cuny.edu

Education:

B.S. Nankai University; M.S. Beijing University and the University of Chicago; Ph.D. Columbia University (with Sam Danishefsky); Postdoc, Columbia University (with Ron Breslow)

Research Summary

Research in the Zheng group focuses on the design and development of new synthetic methodologies and their application to the total synthesis of structurally complex and biologically active natural products.

Targets are selected in terms of novel molecular architecture and intriguing biological activity. In addition to the chemical synthesis of biological relevant target molecules and analogs, additional explorations into their mechanism of action will be made through interdisciplinary collaborations.

Selected Publications

Zhang, G.; Wu, J.; Zeng, H.; Zhang, S.; Yin, Y.; Zheng, S. Cobalt-Catalyzed α-Alkylation of Ketones with Primary Alcohols” Org. Lett., 2017, 19, 1080–1083. DOI: 10.1021/acs.orglett.7b00106

Rampersaud, S.; Fang, J.; Wei, Z.; Fabijanic, K.; Silver, S.; Jaikaran, T.; Ruiz, Y.; Houssou, M.; Yin, Z.; Zheng, S.; Hashimoto, A.; Hoshino, A.; Lyden, D.; Mahajan, S.; Matsui, H. “The Effect of Cage Shape on Nanoparticle-Based Drug Carriers: Anticancer Drug Release and Efficacy via Receptor Blockade Using Dextran-Coated Iron Oxide Nanocages” Nano Lett. 2016, 16, 7357-7363. DOI: 10.1021/acs.nanolett.6b02577

Zhang, G.; Zeng, H.; Wu, J.; Yin, Z.; Zheng, S.; Fettinger, J. C. “Highly Selective Hydroboration of Alkenes, Ketones and Aldehydes Catalyzed by a Well-Defined Manganese Complex” Angew. Chem. Int. Ed. 2016, 55, 14369-14372.  DOI: 10.1002/anie.201607579

Yin, Z.; Zeng, H.; Wu, J.; Zheng, S.; Zhang, G. “Cobalt-Catalyzed Synthesis of Aromatic, Aliphatic, and Cyclic Secondary Amines via a “Hydrogen-Borrowing” Strategy” ACS Catal., 2016, 6, 6546–6550. DOI: 10.1021/acscatal.6b02218

Zhang, G.; Yin, Z.; Zheng, S. “Cobalt-Catalyzed NAlkylation of Amines with Alcohols” Org. Lett. 2016, 18, 300-303. DOI: 10.1021/acs.orglett.5b03461

Yin, Z.; Zhang, S.; Zheng, S.; Golen, J. A.; Rheingold, A. L.; Zhang, G. “Cobalt(II) Coordination Polymers versus Discrete Complex with 4,2:6,4-Terpyridine Ligands: The Role of a Pyrenyl Substituent” Polyhedron, 2015, 101, 139-145. DOI:10.1016/j.poly.2015.09.008

Yin, Z.; Zhang, G.; Phoenix, T; Zheng, S.; Fettinger, J. C. “Assembling mono-, di- and tri-nuclear coordination complexes with a ditopic analogue of 2,2':6',2''-terpyridine: syntheses, structures and catalytic studies” RSC Adv., 2015, 5, 36156-36166. DOI: 10.1039/C5RA06197K

Zheng, S. “Mnemonics for the Aldohexoses That Aid in Learning Structures, Names, and Interconversion of Fischer Projection Formulas and Pyranose Chair Forms” J. Chem. Educ. 2015, 92, 395−398. DOI: 10.1021/ed500254x

Yin, Z.; Zhang, J.; Wu, J.; Green, R.; Li, S.; Zheng, S. “Synthesis of o-Chlorophenols via an Unexpected Nucleophilic Chlorination of Quinone Monoketals Mediated by N, N’-Dimethylhydrazine Dihydrochloride” Org. Biomol. Chem. 2014, 12, 2854-2858. DOI: 10.1039/C4OB00391H

Yin, Z.; Zhang, J.; Wu, J.; Liu, C.; Sioson, K.; Devany, M.; Hu, C.; Zheng, S. “Double Hetero-Michael Addition of N-Substituted Hydroxylamines to Quinone Monoketals: Synthesis of Bridged Isoxazolidines” Org. Lett. 2013, 15, 3534-3537. DOI: 10.1021/ol401235z

Zhang, J.; Yin, Z.; Leonard, P.; Wu, J.; Sioson, K.; Liu, C.; Lapo, R.; Zheng, S. “A Variation of Fischer Indolization Involving Condensation of Quinone Monoketals and Aliphatic Hydrazines” Angew. Chem. Int. Ed., 2013, 52, 1753-1757. DOI: 10.1002/anie.201207533

Zhang, J.; Wu, J.; Yin, Z.; Zeng, H.; Khanna, K.; Hu, C.; Zheng, S. “An Expedient Stereoselective and Chemoselective Synthesis of Bicyclic Oxazolidinones from Quinols and Isocyanates” Org. Biomol. Chem. 2013, 11, 2939-2942. DOI: 10.1039/C3OB00047H

Wu, S.; Wu, J.; Yin, Z.; Zhang, J.; Long, C.; Kennelly, E.; Zheng, S. “Bioactive and Marker Compounds from Two Edible Dark-colored Myrciaria Fruits and the Synthesis of Jaboticabin” J. Agric. Food Chem. 2013, 61, 4035-4043. DOI: 10.1021/jf400487g

Levine, M; Kenesky, C. S.; Zheng, S.; Quinn, J.; Breslow, R. “Synthesis and Catalytic Properties of Diverse Chiral Polyamines” Tetrahedron Lett. 2008, 49, 5746-5750. DOI:10.1016/j.tetlet.2008.07.108

Zheng, S.; Chan, C.; Furuuchi, T.; Wright, B. J. D.; Zhou, B.; Guo, J.; Danishefsky, S. J. “Stereospecific Formal Total Synthesis of Ecteinascidin 743.” Angew. Chem. Int. Ed. 2006, 45, 1754-1759. DOI: 10.1002/anie.200503983

Chan, C.; Zheng, S.; Zhou, B.; Guo, J.; Heid, R. M.; Wright, B. J. D.; Danishefsky, S. J. “The Solution to a Deep Stereochemical Conundrum: Studies toward the Tetrahydroisoquinoline Alkaloids.” Angew. Chem. Int. Ed. 2006, 45, 1749-1754. DOI: 10.1002/anie.200503982

Chan, C.; Heid, R.; Zheng, S.; Guo, J.; Zhou, B.; Furuuchi, T.; Danishefsky, S. J. “Total Synthesis of Cribrostatin IV: Fine-tuning the Character of an Amide Bond by Remote Control.” J. Am. Chem. Soc. 2005, 127, 4596-4598. DOI: 10.1021/ja050203t