Cheryl F. Harding
Ph.D., Rutgers University, Psychobiology
Department of Psychology
695 Park Avenue
New York, NY 10065
Tel: (212) 772-5047
Current Areas of Research:
I have recently switched my research area from behavioral neuroendocrinology in birds to behavioral neuroimmunology in mice. Over the last few years, evidence has mounted that exposure to mold causes a broad range of health problems According to most estimates, about 33-40% of American buildings are moldy. As a neuroscientist, I am particularly intrigued by the effects of mold exposure on neural function and cognition. Recent research has documented that people who lived or worked in moldy buildings had multiple cognitive problems. Compared to controls, mold-exposed individuals in one study scored below the 10th percentile on a number of cognitive tests. In other studies, mold-exposed patients demonstrated neurological deficits that correlated with their cognitive problems. Perhaps one of the most striking findings was that multiple studies concluded that individuals exposed to mold suffered cognitive deficits that could not be distinguished from those of patients suffering from mild traumatic brain injury. In addition, about 20% of Americans appear to be genetically-susceptible to long-term inflammation with resulting medical problems following mold exposure.
My current research seeks to develop a mouse model of the effects of mold exposure on neural and cognitive function. My basic hypothesis is that exposure to mold activates an immune response in the brain just as it does in peripheral tissues like the lungs. Prolonged immune activation is known to cause adverse neurological consequences. First, mice are given basic physiological and cognitive tests. They are then exposed to control or mold stimuli and retested. We compare individuals' performances pre- and post-exposure and as well as looking for differences in performance between groups following mold or control exposures. We then use immunohistochemical techniques to look for differences in brain structure and chemistry between groups following mold exposure. Finally, the animals' performance on the cognitive tests following mold exposure is compared to their measures of physiological and neural function to determine possible relationships.
We have just begun this NIH-funded research and do not yet have any publications in this area.
Rauceo, S., Harding, C.F., Maldonado, A., Gaysinkaya, L., Tulloch, I. and Rodriguez, E. (2008) Dopaminergic modulation of reproductive behavior and activity in male zebra finches. Behavioural Brain Research, 187: 133-137 [PMID: 18160108]
Waterman, S.A. and Harding, C.F. (2008) Neurotoxic effects of DSP-4 on the central noradrenergic system, Behavioural Brain Research, 188: 271-280 [PMID: 18160108]
Vyas, A., Harding, C.F., McGowan, J., Snare, R., and Bogdan, D. (2008) Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata). Behav Neurosci. 122:1148-57. [PMID: 18823170].
Harding, C.F. (2008) Hormonal modulation of singing behavior: Methodology and principles of hormone action. In H.P. Zeigler and P. Marler (Eds.) The Neuroscience of Birdsong: A Multidisciplinary Approach. Cambridge: Cambridge University Press, pp. 305-319.
Vyas, A., Harding, C.F., Borg, L., and Bogdan, D. (2009) Acoustic characteristics, early experience, and endocrine status interact to modulate female zebra finches' behavioral responses to songs. Hormones and Behavior, 55: 50-59 [PMID: 18804474].