ON THE COVER
In this issue, Sharma and colleagues surveyed structures of voltage-gated sodium channels (including the Nav1.5-FHF2 complex solved by Wang et al., Structure 2012) to identify Nav1.5 carboxyl-terminal residues that independently regulate channel activation. inactivation, and modulation in presence of FHF2. Image ® Sharma et al. 2025. See http://doi.org/10.1085/jgp.20253853
The Ph.D. dissertation research of Akshay Sharma is the basis for the January 2026 cover-featured article appearing in Journal of General Physiology. http://doi.org/10.1085/jgp.20253853
