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Research and Discoveries

Latest news:

  1. Thandar M, Lood R, Winer BY, Deutsch DR, Euler CW, Fischetti VA. Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2671-9. doi: 10.1128/AAC.02972-15.
  2. Euler CW, Juncosa B, Ryan PA, Deutsch DR, McShan WM, Fischetti VA. Targeted Curing of All Lysogenic Bacteriophage from Streptococcus pyogenes Using a Novel Counter-selection Technique. PLoS One. 2016 Jan 12;11(1):e0146408. doi: 10.1371/journal.pone.0146408. eCollection 2016.
  3. Wang Q, Euler CW, Delaune A, Fischetti VA. Using a Novel Lysin To Help Control Clostridium difficile Infections. Antimicrob Agents Chemother. 2015 Dec;59(12):7447-57. doi: 10.1128/AAC.01357-15. Epub 2015 Sep 21.
  4. David Foster completed his six year term on the Molecular Oncogenesis (MONC) study section for the National Cancer Institute of the National Institutes of Health.  His final study section was held June 7 – 8 in San Diego CA.
  5. Mandë Holford featured on NPR's All Things Considered with Joe Palca - "Snail Venom Yields Potent Painkiller, But Delivering The Drug Is Tricky"
  6. Mandë Holford on science's role in diplomacy (Science Magazine).
  7. Jill Bargonetti's paper, "Decarbamoyl Mitomycin C (DMC) Activates p53-independent Ataxia Telangiectasia and Rad3 Related Protein (ATR) Chromatin Eviction," has been accepted for publication in Cell Cycle.
  8. Mandë Holford’s work on venomics is featured in October 27 issue of C&E News.
  9. Bio-imaging is the ultimate interdisciplinary advance: fine-scale microscopy allows scientists, including Hunter's bioimaging research group at Belfer, to use advanced physics and chemistry principles to seek and identified diseased cells. The latest boost for this field of research comes from the announcement of 2014 Nobel prize in Chemistry.
  10. Hunter Asst. Professor Chad Euler, Medical Lab Science, receives patent approval for "chimeric bacteriophage lysin with activity against Staphylococci bacteria."
  11. Asst. Professor Mandë Holford, Chemistry, is elected a "New Champion Young Scientist" at World Economic Forum in China.
  12. Hunter's David Foster, a professor of biological sciences, explains the cancer fighting potential of extra virgin olive oil (NBC News 4 New York)
  13. Hunter’s Jill Bargonetti, professor of biological sciences, featured on the PBS special American Graduate Day (VIDEO)

Recent publications by Belfer faculty:

  1. Zhang X, Devany E, Murphy MR, Glazman G, Persaud M, Kleiman FE. PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells. Nucleic Acids Res. 2015 43(22):10925-38.
  2. Meyer, J., Houghton, J., Kozlowski, P., Reiner T., Pillarsetty, N., Scholz, W., Zeglis, B., & Lewis, J. (2015) 18F‑Based Pretargeted PET Imaging Based on Bioorthogonal Diels−Alder Click Chemistry. Bioconjugate Chem., DOI: 10.1021/acs.bioconjchem.5b00504
  3. Anand, P., O’Neil, A., Lin, E., Douglas, T., & Holford, M. (2015). Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers. Sci. Rep., 5(12497). doi:10.1038/srep12497
  4. Holford, M., & Nichols, R. (2015). A tale of two states. Science, 349(6247), 455-455. doi: 10.1126/science.aaa9595
  5. Reiner, T., and Zeglis, B. M.* “The Inverse Electron Demand Diels-Alder Click Reaction in Radiochemistry” J. Labl. Cmpd. Radiopharm. 57(4), 285 (2014).
  6. Zeglis, B. M., Emmetiere, F., Pillarsetty, N., Weissleder, R., Lewis, J. S., Reiner, T. “Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid Phase Peptide Synthesis” Chem. Open. 3, 48 (2014). 
  7. Deri, M., Ponnala, S., Zeglis, B. M., Pohl, G., Dannenberg, J.J., Lewis, J. S., Francesconi, L. C. “An Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)” J. Med. Chem. 57, 4849 (2014).
  8. Wagner, T., Zeglis, B. M., Groveman, S., Francesconi, L.C., Hermann, W. A., Kuhn, F. E., Reiner, T. “Synthesis of the first radiolabeled 188Re N-heterocyclic carbene complex and initial studies on its potential use in radiopharmaceutical applications” J. Label. Cmpd. Radiopharm. 57, 441 (2014).
  9. Price, E. W., Zeglis, B. M., Cawthray, J., Lewis, J. S., Adam, M., Orvig, C. “What a Difference a Carbon Makes: H4Octapa vs. C3H4Octapa, Ligands for 111In and 177Lu Radiochemistry” Inorg. Chem. Online Publication 53, 10412 (2014).
  10. Daumar, P., Zeglis, B. M., Ramos, N., Divilov, V., Sevak, K. K., Pillarsetty, N., Lewis, J. S. “Synthesis and Evaluation of 18F-labeled ATP Competitive Inhibitors of Topoisomerase II as Probes for Imaging Topoisomerase II Expression” Eur. J. Med. Chem. 86, 769 (2014).
  11. Zeglis, B. M., Davis, C. B., Abdel-Atti, D., Carlin, S. D., Chen, A., Aggeler, R., Chen, A., Agnew, B., and Lewis, J. S. “Chemoenzymatic Strategy for the Synthesis of Site-Specifically Labeled Immunoconjugates for Multimodal PET and Optical Imaging” Bioconjugate Chem. 25, 2123 (2014).
  12. Wei, Z., & Matsui, H. (2014). Rational strategy for shaped nanomaterial synthesis in reverse micelle reactors. Nature Communucation, 5(3870). DOI:10.1038/ncomms4870
  13. Foster, D. A. Slloum, D., & Frias, M. A. (2014). Phospholipase D and the maintenance of phosphatidic acid livels of regulation of mammalian target of rapamycin (mTOR). Journal of biological Chemistry, 289 (33), 22583-22588. doi:10.1074/jbc.R114.566091
  14. Yellen, P. & Foster, D. A. (2014). Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Letters, 353(2), 258-263. doi: 10.1016/j.canlet.2014.07.027
  15. Foster, D. A. (2014). In memoriam: Geoffrey Louis Zubay, 1931-2014. Pioneer in cell-free gene expression studies and molecular genetics. Trends in Biochemical Sciences, In Press.  doi: 10.1016/j.tibs.2014.07.007
  16. Rosso, M., Okoro, D. E., & Bargonetti, J. (2014). Splice Variants of MDM2 in Oncogenesis. Subcellular Biochemistry, 85, 246-261. doi: 10.1007/978-94-017-9211-0_14
  17. Saqcena, M., Mukhopadhyay, S., Hosny, C., Alhamed, A., Chatterjee, A., & Foster, D. A. (2014). Blocking anaplerotic entry of flutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs. Ocogene, Advance online publication.  doi: 10.1038/onc.2014.207
  18. Modica, M. V., Puillandre, N., Castelin, M., Zhang, Y., & Holford, M. (2014). A good compromise: Rapid and robust species proxies for inventorying biodiversity hotspots using the terebridae (Gastropoda: Conoidea). PLoS One, 9(7), e102160. doi: 10.1371/journal.pone.0102160
  19. Di, L., Pagan, P.E., Packer, D., Martin, C. L., Akther, S., Ramrattan, G., Mongodin, E. F., Fraser, C. M., Schutzer, . E., Luft, B. J., Casjens, S. R., & Qiu, W.G. (2014). BorreliaBase: a phylogeny-centered browser of Borrelia genomes. BMC Bioinformatics, 15, 233. doi: 10.1186/1471-2105-15-233
  20. Lood, R., Raz, A., Molina, H., Euler, C. W., & Fischetti, V. A. (2014). A highly active and negatively charged Streptococcus pyogenes lysin with a rare D-Alanyl-L-Alanin endopeptidase activity protects mice again streptococcal bacteremia. Antimicrobial Agents and Chemotherapy, 58(6), 3073-3084. doi: 10.1128/AAC.00115-14
  21. Croken, M.M., Qiu, W.G., White, M. W., & Kim K. (2014). Gene Set Enrichment Analysis (GSEA) of Toxoplasma gondii expression datasets links cell cycle progression and the bradyzoite developmental program. BMC Genomics, 15, 515. doi:10.1186/1471-2164-15-51
  22. Shi, M., Shtraizent, N., Polotskaia, A., Bargonetti, J., Matsui, H. (20014). Impedimetric dections of mutant p53 biomarker-driven metastatic breast cancers under hyposmotic pressure. PLoS One, 17, e99351. doi: 10.1371/journal.pone.0099351
  23. Anand, P., Grigoryan, A., Bhuiyan, M. H., Ueberheide, B., Russell, V., Quinonez, J., Moy, P., Chait, B. T., Poget, S. F., & Holford, M. (2014). Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata. PLoS One, 9(4), 394122 doi: 10.1371/journal.pone.0094122
  24. Turkey, D. W., Ferreira, J. M., Antoine, S. O., D'amour, J. A., Ninan, I., de Vaca, S.C., Incontro, S., Wincott, C., Horwitz, J. K., Hartner, D. T., Guarini, C. B., Khatri, L., Goffer, Y., Xu, Duo, Titcombe, R. F., Khatri, M., Marzan, D. S., Mahajan, S. S., Wang, J., Froemke, R. C., Carr, K. D., Aoki, C., & Ziff, E. B. (2013). Sucrose ingestion induces rapid AMPA receptor trafficking. Journal of Neuroscience, 33(14), 6123-6132. doi: 10.1523/JNEUROSCI.4806-12.2013
  25. Qiu W.G. & Martin C.L. (2014) Evolutionary genomics of Borrelia burgdorferi sensu lato: Findings, hypotheses, and the rise of hybrids. Infection Genetics & Evolution, 27, 576-593. doi: 10.1016/j.meegid.2014.03.025
  26. Zhang, Z., Kleiman, F. E., & Devany, E. (2014). Deadenylation and its regulation in eukaryotic cells. In:Rorbach, J. & Bobrowicz, A. J. (Eds.) Polyadenylation: Methods and Protocols, Volume 1125 (289-296). Totowa, NJ: Humana Press Inc. doi: 10.1007/978-1-62703-971-0_23
  27. Hoffman, S., Martin, D., Meléndez, A., Bargonetti, J. (2014). C. elegans CEP-1/p53 and BEC-1 are involved in DNA repair. PLoS One, 9(2), e99929. doi: 10.1371/journal.pone.0088828.
  28. Hasson, T. H., Takaoka, A., de la Rica, R., Matsui, H., Smeureanu, G., Drain, C. M., & Kawamura, A. (2014). Immunostimulatory Lipid Nanoparticles from Herbal Medicine. Chemical, Biology, & Drug Design, 83(4), 493-497. doi: 10.1111/cbdd.12250
  29. Legendre, O., Sookdeo, A., & Foster, D. A. (2014). BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition. Oncology Letters, 7(4), 1165-1168. doi:  10.3892/ol.2014.1833
  30. Cole, C., Krampis, K., Karagiannis, K. Almeida, J.S., Fasion, W. J., Motwani, M. Wan Q., Golikov, A., Pan., Y, Simonyan, V., & Mazumber, R. (2014). Non-synonymous variation in cancer and their effects on the human proteome: workflow for NGS data biocuration and proteome-wide analysis of TCGA data. BMC Bioinformatics, 15, Article Number: 28. doi: 10.1186/1471-2105-15-28
  31. Hy, P., Lim, H., Yoon, YJ, Follenzi, a., Nwokafor, C., Lopez-Jones, M., Meng, X. H., & Singer, R. H. (2014). Visualization of dynamics of single endogenous mRNA labeled in live mouse. Science, 343(6169), 422-424. doi: 10.1126/science.1239200
  32. Salloum, D., Mukhopadhyay, S., Tung, K., Polonetskaya, A., & Foster, D. A. (2014). Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Molecular Cancer Therapy, 13(3), 733-741. doi: 10.1158/1535-7163.MCT-13-0762
  33. Zhao, X, Tian, C., Puszyk, W. M., Ogunwobi, O. O., Cao, M., Wang, T., Cabrera, R., Nelson, D. R., & Liu, C. (2013). OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carinoma. Laboratory Investigation, 93(1), 8-19. doi: 10.1038/labinvest.2012.144
  34. Goss DJ, Kleiman FE. Poly(A) binding proteins: are they all created equal? Wiley Interdiscip Rev RNA. 2013 4(2):167-79.Review.
  35. Einbond, L. S., Mighty, J., Kashiwazaki, R., Figueroa, M., Jalees, F., Acuna, U. M., Le Gendre, O., Foster, D. A.,. & Kennelly, E. J. (2013). Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents in Medicinal Chemistry, 13(10), 1540-1550.
  36. Aggarwal, A., Thompson, S., Singh, S., Newton, B., Moore, A., Goa, R., Gu, X., Mukherjee, S., Drain, C. M. (2014). Photophysics of glycosylated derivatives of chlorin, isobacteriochlorim and bactreiochlorin for photodymanic theragnostics: Discovery of two-photon-absorbing photosensitizer. Photochemistry and Photobiology,90(2), 419-430. doi: 10.1111/php.12179
  37. Sheng, W., Ogunwobi, O. O., Chen, T., Zhang, J., George, T. J., Liu, C., & Fan, Z. H. (2014). Capture, release and culture of a circulating tumor cells from pancreatic cancer patients using an enchanced mixing chip. Lab On A Chip, 14(1), 89-98. doi: 10.1039/c3lc51017d
  38. Okoro, D. R., Arva, N., Gao, C., Polotskaia, A., Puente, C., Rosso, & M., Bargonetti, J. (2013). Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. PLoS One, 8(10), e77643. doi: 10.1371/journal.pone.0077643
  39. Mongodin E.F., Casjens S.R., Bruno J.F., Xu Y., Drabek E.F., Riley D.R., Cantarel B.L., Pagan P.E., Hernandez Y.A., Vargas L.C., Dunn J.J., Schutzer S.E., Fraser C.M., Qiu W.G., & Luft B.J. (2013). Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation. BMC Genomics, 14(1), 693. doi:10.1186/1471-2164-14-693
  40. Jurow, M., Hageman, B. A., DiMasi, E., Nam, Chang-Yong, Pabon, C., Black, C. T., Drain., C. M. (2013). Controlling morphology and molecular packing a alkane substitued phthalocyanine blend bulk heterojunciton solar cells. Journal of Materials Chemistry, 1(5), 1557-1565. doi: 10.1039/c2ta00415a
  41. Jurow, M., Manichev, V., Pabon, C., Hageman, B., Matolina, Y.,& Drain. C. M. (2013). Self-organization of Zr(IV) porphyrinoids on graphene oxide surfaces by axial metal coordination. Inorganic Chemistry,52(18), 10576-10582. doi: 10.1021/ic401563f
  42. Saqcena, M., Menon, D., Patel, D., Mukhopadhyay, S., Chow, V., & Foster, D. A. (2013). Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. PLoS One, 8(8), e74157. doi: 10.1371/journal.pone.0074157
  43. Beales, IL, Garcia-Morales, C., Ogunwobi, O. O., & Mutungi, G. (2014). Adipenectin inhibits leptin-induced oncogenic signaling in oesophageal cancerl cells by activation of PTP1B. Molecular and Cellular Endocrionology, 382(1), 150-158.doi: 10.1016/j.mce.2013.08.013
  44. Jurow, M., Varotto, A., Manichev, V. Travlou, N. A., Giannakoudakis, D. A., & Drain, C. M. (2013). Self-organized nanostructured materials of alkylated phthalocyanines and underivatized C-60 on ITO. RSC Advances, 3(44), 21360-21364. doi: 10.1039/c3ra43795g
  45. Yellen, P., Chatterjee, A., Preda, A., & Foster, D. A. (2013). Inhibition of S6 kinas suppresses the apoptotic effect of elF4E ablation by inducing TGF-ß-dependent G1 cell cycle arrest. Cancer Letter, 333(2), 239-243. 10.1016/j.canlet.2013.01.041
  46. Foster, D. A. (2013). Phosphatidic acid and lipid-sensing by mTOR. Trends in Endocrinology and Metabolism, 24(6), 272-278. doi: 10.1016/j.tem.2013.02.003
  47. Gilmer, D. B, Schmitz, J. E., Euler, C. W., & Fischetti, V. A. (2013). Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherarpy, 57(6), 2743-2750. doi: 10.1128/AAC.02526-12
  48. Ogunwobi, O. O., Puszyk, W., Dong, H. J., & Liu, C. (2013). Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carinoma. PloS One, 8(5), e63765. doi: 10.1371/journal.pone.0063765
  49. Yelskaya, Z., Carrillo, V., Dubisz, E., Gulzar, H., Morgan, D., Mahajan, S. S. (2013). Synergistic Inhibition of survival, Proliferation, and Migration of U87 Cells with a Combination of LY341495 and Iressa. PLoS One, 8(5),1-10. doi: 10.1371/journalpone.0064588
  50. Zeglis, B.M., Sevak, K. K., Reiner, T. Mohindra, P. Carlin, S. D., Zanzonico, P., Weissleder, R., & Lewis, J. S. (2013). A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry. Journal of Nuclear Medicine, 54(8), 1389-1396. doi: 10.2967/jnumed.112.115840
  51. Zeglis, B. M., Davis, C. B., Aggeler, R., Kang, H. C. Chen, A., Agnew, B. J., & Lewis, J. S. (2013). Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry. Bioconjugate Chemistry, 24(6),1057-1067. doi: 10.1021/bc400122c
  52. Le Gendre, O., Sookdeo, A., Duliepre, S. A. Utter, M., Frias, M. & Foster, D. A. (2013). Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells. Molecular Cancer Research, 11(5), 474-481.  doi: 10.1158/1541-7786.MCR-12-0679.Goss, D. J., & Kleiman, F. E. (2013). Poly(A) binding proteins: are they all created equal? Wiley Interdisciplinary Reviews, RNA, 4(2), 167-179. doi: 10.1002/wrna.1151
  53. Zeng, D., Zeglis, B. M., Lewis, J. S., & Anderson, C. J. (2013). The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals. Journal of Nuclear Medicine, 54(6), 829-832. doi: 10.2967/jnumed.112.115550
  54. Schuch, R., Pelzek, A. J., Raz, A., Euler, C.W., Ryan, P. A., Winer, B. Y., Farnsworth, A., Bhaskaran, S. S., Stebbins, C. E., Xu, Y., Clifford, A., Bearss, D. J., Vankayalapati, H., Golberg, A. R., & Fischetti, V. A. (2013). Use of bacteriophage lysin to identify a novel targe for antimicrobial development. PLoS One, 8(4), e60754. doi: 10.1371/journal.pone.0060754
  55. Devany, E., Zhang, X., Park, J. Y., Tian, B., & Kleiman, F. E. (2013). Positive and negative feedback loops in the p53 and mRNA 3' processing pathways. Proceedings of the National Academy of Sciences of the United States of America, 110(9), 3351-3356. doi: 10.1073/pnas.1212533110
  56. Deri, M. A., Zeglis, B. M., Francesconi, L. C., & Lewis, J. S. (2013) PET imaging with Zr-89: From radiochemistry to the clinic. Nuclear Medicine and Biology, 40(1), 3-14. doi:10.1016/j.nucmedbio.2012.08.004
  57. Radivojevic, I., Ithisuphalap, K., Burton-Pye, B. P., Saleh, Raihan, F., Lynn, C., & Drain, C. M. (2013). Ternary phthalocyanato Hf(IV) and Zr(IV) polyoxometalate complexes. RSC Advances, 3(7), 2174-2177. doi: 10.1039/c2ra22903j 
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